Cytochalasins block actin filament elongation by binding to high affinity sites associated with F-actin.

@article{Flanagan1980CytochalasinsBA,
  title={Cytochalasins block actin filament elongation by binding to high affinity sites associated with F-actin.},
  author={Michael D. Flanagan and Shuangjun Lin},
  journal={The Journal of biological chemistry},
  year={1980},
  volume={255 3},
  pages={835-8}
}
We have found that addition of a small amount of filamentous muscle actin (F-actin) to a solution of globular actin (G-actin) in a low ionic strength medium resulted in rapid polymerization of the G-actin. This reaction was inhibited by substoichiometric levels of cytochalasins (relative potency: cytochalasin D greater than cytochalasin E approximately equal to cytochalasin B greater than dihydrocytochalasin B). Binding experiments show that F-actin, but not G-actin, contains high affinity… CONTINUE READING
114 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 114 extracted citations

Similar Papers

Loading similar papers…