Cytoadherence of knobless Plasmodium falciparum-infected erythrocytes and its inhibition by a human monoclonal antibody

@article{Udomsangpetch1989CytoadherenceOK,
  title={Cytoadherence of knobless Plasmodium falciparum-infected erythrocytes and its inhibition by a human monoclonal antibody},
  author={Rachanee Udomsangpetch and Masamichi Aikawa and Klavs Berzins and Mats Wahlgren and Peter Perlmann},
  journal={Nature},
  year={1989},
  volume={338},
  pages={763-765}
}
RED blood cells infected with mature stages of the malaria parasite Plasmodium falciparum bind to the endothelial lining of capillaries and venules. This sequestration is important for the survival of the parasite but may have severe consequences for the host. For example, it is involved in the causation of cerebral malaria which carries 25% mortality1–5. Knob-like protrusions present on the surface of infected erythrocytes have been considered necessary but not sufficient for this… CONTINUE READING

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