Cytisine modulates chronic voluntary ethanol consumption and ethanol-induced striatal up-regulation of ΔFosB in mice.

@article{Sajja2013CytisineMC,
  title={Cytisine modulates chronic voluntary ethanol consumption and ethanol-induced striatal up-regulation of $\Delta$FosB in mice.},
  author={Ravi K Sajja and Shafiqur Rahman},
  journal={Alcohol},
  year={2013},
  volume={47 4},
  pages={
          299-307
        }
}
Chronic administration of ethanol induces persistent accumulation of ΔFosB, an important transcription factor, in the midbrain dopamine system. This process underlies the progression to addiction. Previously, we have shown that cytisine, a neuronal nicotinic acetylcholine receptor (nAChR) partial agonist, reduces various ethanol-drinking behaviors and ethanol-induced striatal dopamine function. However, the effects of cytisine on chronic ethanol drinking and ethanol-induced up-regulation of… Expand
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