Cytisine inhibits the protective activity of various classical and novel antiepileptic drugs against 6 Hz-induced psychomotor seizures in mice

@article{Tutka2016CytisineIT,
  title={Cytisine inhibits the protective activity of various classical and novel antiepileptic drugs against 6 Hz-induced psychomotor seizures in mice},
  author={Piotr Tutka and Maria W. Kondrat-Wr{\'o}bel and Katarzyna Zaluska and Dorota Ż{\'o}łkowska and Magdalena Florek-Łuszczki and Jarogniew Jacek Łuszczki},
  journal={Psychopharmacology},
  year={2016},
  volume={234},
  pages={281-291}
}
Cytisine (CYT) is a partial agonist of brain α4β2 nicotinic acetylcholine receptors widely used in Central/Eastern Europe for smoking cessation. This study evaluated the effect of CYT on the ability of classical and novel antiepileptic drugs to prevent seizures evoked by the 6-Hz test, a model of psychomotor seizures in mice thought as a model of drug-resistant seizures. CYT administered intraperitoneally (i.p.) in a dose of 2 mg kg−1 significantly inhibited the anticonvulsant activity of… CONTINUE READING

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