Cytidine monophospho-N-acetylneuraminic acid hydroxylase (CMAH) mutations associated with the domestic cat AB blood group

@article{Bighignoli2007CytidineMA,
  title={Cytidine monophospho-N-acetylneuraminic acid hydroxylase (CMAH) mutations associated with the domestic cat AB blood group},
  author={Barbara Bighignoli and Tirri Niini and Robert A. Grahn and Niels C Pedersen and Lee V. Millon and Michele Polli and M Longeri and Leslie A. Lyons},
  journal={BMC Genetics},
  year={2007},
  volume={8},
  pages={27 - 27}
}
BackgroundThe cat has one common blood group with two major serotypes, blood type A that is dominant to type B. A rare type AB may also be allelic and is suspected to be recessive to A and dominant to B. Cat blood type antigens are defined, N-glycolylneuraminic acid (NeuGc) is associated with type A and N-acetylneuraminic acid (NeuAc) with type B. The enzyme cytidine monophospho-N-acetylneuraminic acid hydroxylase (CMAH) determines the sugar bound to the red cell by converting NeuAc to NeuGc… Expand
Molecular Characterization of the Cytidine Monophosphate-N-Acetylneuraminic Acid Hydroxylase (CMAH) Gene Associated with the Feline AB Blood Group System
TLDR
Results suggested that double haploids selected from multiple recessive alleles in the cat CMAH loci were highly associated with the expression of the Neu5Ac on erythrocyte membrane in types B and AB of the feline AB blood group system. Expand
A Novel Variant in CMAH Is Associated with Blood Type AB in Ragdoll Cats
TLDR
A novel variant, c.364C>T, was identified that is highly associated with blood type AB in Ragdoll cats and, to a lesser degree, withtype AB in random bred cats. Expand
Analysis of cytidine monophospho-N-acetylneuraminic acid hydroxylase (CMAH) gene related to neonatal isoerythrolysis in stray cats of Izmir, Turkey.
TLDR
The results show that the potential of neonatal isoerythrolysis in stray cats of İzmir is minimal, and future studies are required to scrutinize the reason(s) for non-existence of type B cats in İZmir and presence of unique band in blood type AB. Expand
Molecular characterization of cytidine monophospho-N-acetylneuraminic acid hydroxylase (CMAH) associated with the erythrocyte antigens in dogs
TLDR
The results obtained in this study provide essential information that will help in understanding the molecular roles of the CMAH gene in canine erythrocyte antigens and identify single nucleotide polymorphisms (SNPs) in the C MAH gene. Expand
Molecular characterization of cytidine monophospho-N-acetylneuraminic acid hydroxylase (CMAH) gene and frequency of blood types in stray cats of İzmir, Turkey
TLDR
The presence of a new SNP as well as previous SNPs indicates that more variations can be found in stray cats with a more comprehensive study in the future. Expand
Molecular characterization of blood type A, B, and C (AB) in domestic cats and a CMAH genotyping scheme
TLDR
The three CMAH variants c.179G>T, c.268T>A and c.1322delT are the main reasons for the defective NeuGc synthesis causing blood type B in domestic purebred and non-pedigreed cats. Expand
Phylogenetic Distribution of CMP-Neu5Ac Hydroxylase (CMAH), the Enzyme Synthetizing the Proinflammatory Human Xenoantigen Neu5Gc
TLDR
This work produces a list of animals inferred to be free from endogenous Neu5Gc based on the absence of CMAH homologs and are thus potential candidates for human consumption, xenotransplantation research, and model organisms for investigation of human diseases. Expand
Phenotypic and Genetic Characterization for Incompatible Cross-Match Cases in the Feline AB Blood Group System
The feline AB blood group system (blood types A, B, and AB) encoding the cytidine monophosphate-N-acetylneuraminic acid hydroxylase (CMAH) gene is the most significant in transfusion medicine andExpand
High-performance liquid chromatography ganglioside pattern of the AB feline blood group
TLDR
Ganglioside patterns from A and AB blood types cats diverged from the serological classification, with N-acetylneuraminic and N-glycolylneuraminationic derivate gangliosides confirmed as major determinants in feline blood types. Expand
CMAH genotyping survey for blood types A, B and C (AB) in purpose-bred cats.
TLDR
The new SNV panel is superior in genotyping cats than the originalSNV panel and assures correct assignments of types A, B and C to assist veterinary clinicians and breeders to recognize, confirm and avoid blood incompatibilities such as acute hemolytic transfusion reactions and NI. Expand
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