Cytidine Deamination of Retroviral DNA by Diverse APOBEC Proteins

  title={Cytidine Deamination of Retroviral DNA by Diverse APOBEC Proteins},
  author={Kate N Bishop and Rebecca K. Holmes and Ann M. Sheehy and Nicholas O. Davidson and Soo Jin Cho and Michael H Malim},
  journal={Current Biology},
The human cytidine deaminase APOBEC3G edits both nascent human immunodeficiency virus (HIV) and murine leukemia virus (MLV) reverse transcripts, resulting in loss of infectivity. The HIV Vif protein is able to protect both viruses from this innate restriction to infection. Here, we demonstrate that a number of other APOBEC family members from both humans and rodents can mediate anti-HIV effects, through cytidine deamination. Three of these, rat APOBEC1, mouse APOBEC3, and human APOBEC3B, are… CONTINUE READING
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