Cytidine Deamination of Retroviral DNA by Diverse APOBEC Proteins

@article{Bishop2004CytidineDO,
  title={Cytidine Deamination of Retroviral DNA by Diverse APOBEC Proteins},
  author={Kate N Bishop and Rebecca K. Holmes and Ann M. Sheehy and Nicholas O. Davidson and Soo Jin Cho and Michael H Malim},
  journal={Current Biology},
  year={2004},
  volume={14},
  pages={1392-1396}
}
The human cytidine deaminase APOBEC3G edits both nascent human immunodeficiency virus (HIV) and murine leukemia virus (MLV) reverse transcripts, resulting in loss of infectivity. The HIV Vif protein is able to protect both viruses from this innate restriction to infection. Here, we demonstrate that a number of other APOBEC family members from both humans and rodents can mediate anti-HIV effects, through cytidine deamination. Three of these, rat APOBEC1, mouse APOBEC3, and human APOBEC3B, are… CONTINUE READING
Highly Influential
This paper has highly influenced 33 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 288 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 33 references

Single - strand specificity of APOBEC 3 G accounts for minusstrand desynthesis in infected cells

  • J. M. Coffin, N. R. Landau
  • J . Virol .
  • 2004

Singlestrand specificity of APOBEC3G accounts for minus-strand

  • D. Richman, J. M. Coffin, N. R. Landau
  • 2004

Similar Papers

Loading similar papers…