Cystine accumulation in the CNS results in severe age-related memory deficits

@article{Maurice2009CystineAI,
  title={Cystine accumulation in the CNS results in severe age-related memory deficits},
  author={Tangui Maurice and Claire Hippert and Nicolas Serratrice and Gr{\'e}gor Dubois and Chantal Jacquet and Corinne Antignac and Eric J Kremer and Vasiliki Kalatzis},
  journal={Neurobiology of Aging},
  year={2009},
  volume={30},
  pages={987-1000}
}
Cystinosis is a lysosomal storage disorder characterised by progressive cystine accumulation. The causative gene, CTNS, encodes cystinosin, the lysosomal cystine transporter. Neurological deterioration is one of the last symptoms to appear and the least well characterised. Visuospatial memory deficits have been documented in patients. To determine whether the cystinosis mouse model presents similar anomalies, we studied the learning and memory abilities of young and middle-aged Ctns(-/-) mice… CONTINUE READING
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