Cystin, a novel cilia-associated protein, is disrupted in the cpk mouse model of polycystic kidney disease.

@article{Hou2002CystinAN,
  title={Cystin, a novel cilia-associated protein, is disrupted in the cpk mouse model of polycystic kidney disease.},
  author={Xiaoying Hou and Michal M Mrug and Bradley K. Yoder and Elliot J. Lefkowitz and Gabriel Kremmidiotis and Peter D'Eustachio and David R Beier and L. M. Guay-Woodford},
  journal={The Journal of clinical investigation},
  year={2002},
  volume={109 4},
  pages={533-40}
}
The congenital polycystic kidney (cpk) mutation is the most extensively characterized mouse model of polycystic kidney disease (PKD). The renal cystic disease is fully expressed in homozygotes and is strikingly similar to human autosomal recessive PKD (ARPKD), whereas genetic background modulates the penetrance of the corresponding defect in the developing biliary tree. We now describe the positional cloning, mutation analysis, and expression of a novel gene that is disrupted in cpk mice. The… CONTINUE READING
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An integrated genetic and physical map of the 650kb interval containing the congenital polycystic kidney (cpk) locus on mouse

  • M Mrug
  • Chromosome 12. Cytogenet. Cell Genet
  • 2001
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