Cystic renal neoplasia following conditional inactivation of apc in mouse renal tubular epithelium.

@article{Qian2005CysticRN,
  title={Cystic renal neoplasia following conditional inactivation of apc in mouse renal tubular epithelium.},
  author={Chao-nan Qian and Jared Knol and Peter Igarashi and Fangming Lin and Uko Zylstra and Bin Tean Teh and Bart O. Williams},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 5},
  pages={3938-45}
}
Alterations in Wnt/beta-catenin signaling have been linked to abnormal kidney development and tumorigenesis. To gain more insights into the effects of these alterations, we created mice carrying a conditional deletion of the Apc tumor suppressor gene specifically in the renal epithelium. As expected, the loss of Apc leads to increased levels of beta-catenin protein in renal epithelium. Most of these mice die shortly after birth, and multiple kidney cysts were found upon histological examination… CONTINUE READING

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