Cystic lymph node metastasis in patients with head and neck cancer: An HPV‐associated phenomenon

  title={Cystic lymph node metastasis in patients with head and neck cancer: An HPV‐associated phenomenon},
  author={David M. Goldenberg and Shahnaz Begum and William H. Westra and Zubair Khan and James J. Sciubba and Sara I. Pai and Joseph A. Califano and Ralph Patrick Tufano and Wayne M Koch},
  journal={Head \& Neck},
BACKGROUND : Cystic lymph node metastases have been associated with tonsil cancer. [] Key MethodRESULTS : One hundred neck dissections were reviewed and 20 had cystic nodes. Seventeen of these patients had primary tumors arising in the palatine or lingual tonsil. Three were "unknown primary." HPV DNA was present in 11 of 13 patients with cystic metastases with tissue available for analysis (87%). No HPV DNA was identified in tumor from 21 patients with solid nodal metastasis (p <.0001). CONCLUSION : Cystic…

Prevalence and impact on clinicopathological characteristics of human papillomavirus‐16 DNA in cervical lymph node metastases of head and neck squamous cell carcinoma

Human papillomavirus (HPV) is a basic risk factor for head and neck squamous cell carcinoma (HNSCC). Little knowledge exists about the impact of HPV on clinical diagnostic and therapy of patients

Squamous Cell Carcinoma Metastasis to Neck Lymph Node of Unknown Baseline Tumor in HPV Positive Patient. Case Report.

The most common neck masses in adults are neoplastic in nature, so they should be treated as neoplasms until the diagnosis turns out otherwise.

High‐risk human papillomavirus and cervical lymph node metastasis in patients with oropharyngeal cancer

The purpose of this study was to determine the role of high‐risk human papillomavirus (HPV) in lymph node metastasis and the depth of invasion in oropharyngeal cancer.

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This is a brief communication stressing some critical points associated with cystic nodal metastasis (CNM) in human papillomavirus (HPV) positive oropharyngeal squamous cell carcinoma (OPSCC) and its

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The purpose of the study was to investigate the imaging characteristics of nodal metastasis by HPV status in HNSCC and to clarify whether those findings influence the outcomes.

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Human papillomavirus (HPV)‐related squamous cell carcinoma of unknown primary (SCCUP) is currently rising in incidence but lacks a validated management approach.

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To determine whether muscle invasion evident on pretreatment imaging in p16 + oropharyngeal squamous cell carcinoma (OPSCC) correlates with recurrence, Pretreatment Imaging is used as a surrogate for recurrence.

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A practical approach to HPV testing within the setting of the diagnostic histopathology laboratory is described.



Incidence of Unsuspected Metastases in Lateral Cervical Cysts

The incidence of solitary cystic squamous cell carcinoma metastasis in patients presenting with apparently benign cervical cysts is identified.

Cystic change in lymph nodes with metastatic squamous cell carcinoma.

A retrospective analysis was performed of the gross characteristics of aspirated material in 335 consecutive cases of metastatic squamous cell carcinoma in cervical/supraclavicular lymph nodes seen during a three-year period, finding cystic change in lymph nodes harboring metastatic Squamous Cell carcinoma was frequently associated with a tongue primary.

Cervical cysts: Cancer until proven otherwise?

A cystic neck mass can be either malignant or benign; 22% of patients (4/18) admitted with the tentative diagnosis of branchial cyst in a recent 2‐year period (1977‐1979) had metastatic carcinoma:

Cystic lymph node metastases of squamous cell carcinoma of Waldeyer's ring origin

The frequency of cystic lymph node (LN) metastases in neck dissection specimens of 123 patients with primary squamous cell carcinoma arising in the palatine tonsils, the base of the tongue and the nasopharynx was analysed.

Detection of Human Papillomavirus-16 in Fine-Needle Aspirates to Determine Tumor Origin in Patients with Metastatic Squamous Cell Carcinoma of the Head and Neck

HPV16 status can be determined in tumor cells aspirated from the necks of patients with metastatic HNSCC, and its presence is a reliable indicator of origin from the oropharynx.

Cervical node metastases presenting with features of branchial cysts

Nine out of 270 patients presenting with a neck mass — which proved to contain a squamous carcinoma were investigated, finding that 16 per cent of branchial cysts in this series represented metastases from squamous cell carcinoma.

False‐negative diagnosis in fine‐needle aspirations of squamous‐cell carcinoma of head and neck

Several diagnostic problems and pitfalls that might be seen in FNAs ofSquamous‐cell carcinoma, including cystic changes, well‐differentiated SCC, spindled S CC, and SCC with foreign‐body giant cells, keratin plaques, and ghost cells are described.

Evidence for a causal association between human papillomavirus and a subset of head and neck cancers.

It is suggested that HPV-positive oropharyngeal cancers comprise a distinct molecular, clinical, and pathologic disease entity that is likely causally associated with HPV infection and that has a markedly improved prognosis.

Untimely lymph node biopsy.

  • H. Martin
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  • 1961

Branchial cyst—to endoscope or not?

Endoscopy, ipsilateral tonsillectomy and blind biopsies of Waldeyer's ring, combined with excision of the cervical lesion are recommended in patients over 40 years old.