Cystic fibrosis transmembrane conductance regulator (CFTR) expression in human platelets: impact on mediators and mechanisms of the inflammatory response.

@article{Mattoscio2010CysticFT,
  title={Cystic fibrosis transmembrane conductance regulator (CFTR) expression in human platelets: impact on mediators and mechanisms of the inflammatory response.},
  author={Domenico Mattoscio and V Shirley Evangelista and Raimondo de Cristofaro and Antonio Recchiuti and Assunta Pandolfi and Sara Di Silvestre and Stefano Manarini and Nicola Martelli and Bianca Rocca and Giovanna Petrucci and Daniela Francesca Angelini and Lucia Battistini and Iole Robuffo and Salvatore Leonardi and Luisa Pieroni and Maria Lucia Furnari and Fernando Jos{\'e} Delai Pardo and Serena Quattrucci and Stefano Lancellotti and Giovanni Dav{\'i} and M{\'a}rio Romano},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2010},
  volume={24 10},
  pages={
          3970-80
        }
}
Inflammatory lung disease is a primary cause of morbidity and mortality in cystic fibrosis (CF). Mechanisms of unresolved acute inflammation in CF are not completely known, although the involvement of cystic fibrosis transmembrane conductance regulator (CFTR) in nonrespiratory cells is emerging. Here we examined CFTR expression and function in human platelets (PLTs) and found that they express a biologically active CFTR. CFTR blockade gave an ∼50% reduction in lipoxin A(4) (LXA(4)) formation… CONTINUE READING
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