Cystic fibrosis transmembrane conductance regulator and caveolin-1 regulate epithelial cell internalization of Pseudomonas aeruginosa.

@article{Bajmoczi2009CysticFT,
  title={Cystic fibrosis transmembrane conductance regulator and caveolin-1 regulate epithelial cell internalization of Pseudomonas aeruginosa.},
  author={Milan Bajmoczi and Mihaela G. Gadjeva and Seth L Alper and Gerald B Pier and David Golan},
  journal={American journal of physiology. Cell physiology},
  year={2009},
  volume={297 2},
  pages={
          C263-77
        }
}
Patients with cystic fibrosis (CF) exhibit defective innate immunity and are susceptible to chronic lung infection with Pseudomonas aeruginosa. To investigate the molecular bases for the hypersusceptibility of CF patients to P. aeruginosa, we used the IB3-1 cell line with two defective CF transmembrane conductance regulator (CFTR) genes (DeltaF508/W1282X) to generate isogenic stable, clonal lung epithelial cells expressing wild-type (WT)-CFTR with an NH(2)-terminal green fluorescent protein… CONTINUE READING
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