Cystic fibrosis transmembrane conductance regulator. Structure and function of an epithelial chloride channel.

@article{Akabas2000CysticFT,
  title={Cystic fibrosis transmembrane conductance regulator. Structure and function of an epithelial chloride channel.},
  author={Myles H. Akabas},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 6},
  pages={3729-32}
}
The cystic fibrosis transmembrane conductance regulator (CFTR) forms a Cl channel that is an essential component of epithelial Cl transport systems in many organs, including the intestines, pancreas, lungs, sweat glands, and kidneys. In the Cl secretory intestinal epithelium, Cl enters the cells through a Na-K-2Cl cotransporter in the basolateral membrane and exits through CFTR in the apical membrane; water follows osmotically (1). Absorptive epithelia use similar transporters and channels, but… CONTINUE READING

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Minireview: CFTR Channel Structure and Function

M. A. Loo, T. J. Jensen, +3 authors J. R. Riordan
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