• DOI:10.1164/RCCM.200505-840OE
Corpus ID: 1770759

Cystic fibrosis since 1938.

@article{Davis2006CysticFS,
  title={Cystic fibrosis since 1938.},
  author={P. Davis},
  journal={American journal of respiratory and critical care medicine},
  year={2006},
  volume={173 5},
  pages={
          475-82
        }
}

P. Davis

Published 2006

Medicine

American journal of respiratory and critical care medicine

Cystic fibrosis (CF) was distinguished from celiac disease in 1938. Then, it was a pathologic diagnosis, life expectancy was approximately 6 months, and the autosomal recessive disease was believed to arise from abnormal mucus plugging exocrine ducts. Death often occurred from lung infection. Discovery of the sweat electrolyte defect in 1953 and standardization of the sweat test in 1959 allowed identification of milder cases, and CF was no longer considered only a disorder of mucus. In 1955… CONTINUE READING

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