Cystic fibrosis pathogens activate Ca2+-dependent mitogen-activated protein kinase signaling pathways in airway epithelial cells.

@article{Ratner2001CysticFP,
  title={Cystic fibrosis pathogens activate Ca2+-dependent mitogen-activated protein kinase signaling pathways in airway epithelial cells.},
  author={Adam J Ratner and R. K. Bryan and Artur Aron Weber and Steven Nguyen and David Preston Barnes and Allyson S. Pitt and Shari I Gelber and Ambrose Cheung and Alice Prince},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 22},
  pages={19267-75}
}
Much of the pulmonary disease in cystic fibrosis is associated with polymorphonuclear leukocyte-dominated airway inflammation caused by bacterial infection. Respiratory epithelial cells express the polymorphonuclear chemokine interleukin-8 (IL-8) in response to ligation of asialylated glycolipid receptors, which are increased on damaged or regenerating cells and those with cystic fibrosis transmembrane conductance regulator mutations. Because both Pseudomonas aeruginosa and Staphylococcus… CONTINUE READING

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American journal of physiology. Lung cellular and molecular physiology • 2007
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