Cystic fibrosis gene expression is not correlated with rectifying Cl- channels.

@article{Ward1991CysticFG,
  title={Cystic fibrosis gene expression is not correlated with rectifying Cl- channels.},
  author={Cristina L. Ward and Mauri E. Krouse and Dieter C. Gruenert and Ron R. Kopito and Jeffery J Wine},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1991},
  volume={88 12},
  pages={5277-81}
}
Cystic fibrosis (CF) involves a profound reduction of Cl- permeability in several exocrine tissues. A distinctive, outwardly rectifying, depolarization-induced Cl- channel (ORDIC channel) has been proposed to account for the Cl- conductance that is defective in CF. The recently identified CF gene is predicted to code for a 1480-amino acid integral membrane protein termed the CF transmembrane conductance regulator (CFTR). The CFTR shares sequence similarity with a superfamily of ATP-binding… CONTINUE READING

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