Cystic fibrosis associated islet changes may provide a basis for diabetes

  title={Cystic fibrosis associated islet changes may provide a basis for diabetes},
  author={Matthias L{\"o}hr and P. Goertchen and Horst Nizze and Natalie S. Gould and Victor E. Gould and M. Oberholzer and Ph. U. Heitz and G. Kl{\"o}oppel},
  journal={Virchows Archiv A},
The pancreases of 23 patients (mean age 10.5 years, range 5-22) years dying of cystic fibrosis (CF) were evaluated at autopsy by routine histology and immunostaining for changes in their endocrine cell compartment. The severely altered pancreatic tissues showed end stage CF, with either a fibrotic pattern (CF-FIB,n=14) or a lipoatrophic pattern (CF-LIP,n=9) prevailing. In all specimens, irrespective of the dominating pattern, the islet system was affected by marked periinsular and intrainsular… CONTINUE READING
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