Cystic fibrosis airway epithelial Ca2+ i signaling: the mechanism for the larger agonist-mediated Ca2+ i signals in human cystic fibrosis airway epithelia.

@article{Ribeiro2005CysticFA,
  title={Cystic fibrosis airway epithelial Ca2+ i signaling: the mechanism for the larger agonist-mediated Ca2+ i signals in human cystic fibrosis airway epithelia.},
  author={Carla Maria Pedrosa Ribeiro and Anthony M. Paradiso and Mark A. Carew and Stephen B Shears and Richard C. Boucher},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 11},
  pages={10202-9}
}
In cystic fibrosis (CF) airways, abnormal epithelial ion transport likely initiates mucus stasis, resulting in persistent airway infections and chronic inflammation. Mucus clearance is regulated, in part, by activation of apical membrane receptors coupled to intracellular calcium (Ca(2+)(i)) mobilization. We have shown that Ca(2+)(i) signals resulting from apical purinoceptor (P2Y(2)-R) activation are increased in CF compared with normal human airway epithelia. The present study addressed the… CONTINUE READING
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