• Corpus ID: 23128077

Cystic fibrosis: model of pathogenesis based on the apical membrane potential.

@article{Kurbel2015CysticFM,
  title={Cystic fibrosis: model of pathogenesis based on the apical membrane potential.},
  author={Beatrica Kurbel and Sa{\vs}a Rapan and Sven Kurbel},
  journal={Medicinski glasnik : official publication of the Medical Association of Zenica-Doboj Canton, Bosnia and Herzegovina},
  year={2015},
  volume={12 1},
  pages={
          1-6
        }
}
  • B. KurbelS. RapanS. Kurbel
  • Published 1 February 2015
  • Biology, Medicine
  • Medicinski glasnik : official publication of the Medical Association of Zenica-Doboj Canton, Bosnia and Herzegovina
A simple model of cystic fibrosis (CF) is proposed, based on the apical membrane (ApM) potential. The ApM of epithelial cells is highly permeable to sodium and activation of CFTRs makes it permeable to chloride. Calculated ApM potentials of cells with activated cystic fibrosis transmembrane conductance regulators (CFTRs) are between the sodium and chloride Nernst values and thus allow rapid absorption of both ions in exocrine glands. In CF patients the potential is near the sodium Nernst value… 

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