Cystic fibrosis: lessons from the sweat gland.

@article{Quinton2007CysticFL,
  title={Cystic fibrosis: lessons from the sweat gland.},
  author={Paul Marquis Quinton},
  journal={Physiology},
  year={2007},
  volume={22},
  pages={
          212-25
        }
}
Lessons from the sweat gland on cystic fibrosis (CF) began long before modern medicine became a science. In European folklore, the curse that "a child that taste salty when kissed will soon die" (Alonso y de los Ruyzes de Fonteca J. Diez Previlegios para Mugeres Prenadas. Henares, Spain, 1606) has been taken by many as a direct reference to cystic fibrosis [Busch R. Acta Univ Carol Med (Praha) 36: 13-15, 1990]. The high salt concentration in sweat from patients with CF is now accepted as almost… 
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Citation Type

Atypical cystic fibrosis: identification in the primary care setting.
  • C. Schram
  • Medicine
    Canadian family physician Medecin de famille canadien
  • 2012
TLDR
Although patients diagnosed with atypical CF have longer life expectancies than individuals with classic CF, the long-term expected outcome for many individuals with attypical CF is unknown and it is important to counsel patients about the possibility of future illness.
Cystic fibrosis: a clinical view
TLDR
Despite the increasing understanding of CFTR functioning, several aspects of CF need still to be clarified, e.g., the worse outcome in females, the risk of malignancies, the pathophysiology, and best treatment of comorbidities, such as CF-related diabetes or CF- related bone disorder.
[Cystic fibrosis].
TLDR
The key role in management of CF is treating of airway infection and encourages the patient to an active life style and using high energy content food, as well as maintaining of organ functioning and delay organ dysfunctions.
Cystic fibrosis.
  • N. Radlović
  • Medicine
    Srpski arhiv za celokupno lekarstvo
  • 2012
TLDR
The clinical features of patients with CF are predominated by respiratory, digestive and reproductive disorders, as well as the tendency to dehydration in the condition of increased sweating, which requires multidisciplinary therapeutic approach.
Cystic Fibrosis: Pathophysiology of Lung Disease.
TLDR
The purpose of this review is to summarize the current knowledge of CF pathophysiology, including significant historic discoveries and most recent breakthroughs, and to improve understanding and awareness of this fatal disease.
Sixty‐five years since the New York heat wave: Advances in sweat testing for cystic fibrosis
TLDR
The sweat test remains important as a diagnostic test for cystic fibrosis (CF) and there remain issues with adherence to sweat test guidelines in many countries and there are gaps in knowledge, including reference intervals for some age groups and stability of sweat samples in transport.
Cystic Fibrosis Diagnosis in Newborns, Children, and Adults.
TLDR
In older patients with a late diagnosis, the spectrum of clinical presentation can be very variable with vigilant clinicians from multiple specialties suspecting the diagnosis in conditions such as recurrent pulmonary infections, male infertility, pancreatitis, nasal polyposis, and malabsorption.
Presentation of an infant with nutritional deficiency dermatitis as the initial manifestation of cystic fibrosis.
TLDR
The authors' experience indicates that NDD, as the initial manifestation of CF, should be also kept in mind in differential diagnosis of the infant's AD-like changes.
Current and future diagnosis of cystic fibrosis: Performance and limitations.
TLDR
The methods and molecular approaches that are used in routine practice or are being developed to detect CFTR protein dysfunction and to identify disease-causing CFTR variants are described.
Sweat gland bioelectrics differ in cystic fibrosis: a new concept for potential diagnosis and assessment of CFTR function in cystic fibrosis
TLDR
The concept that skin surface voltages arising from stimulated sweat glands can be exploited to assess expressed CFTR function in vivo and may prove to be a useful diagnostic tool is supported.
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