Cystic fibrosis: lessons from the sweat gland.

@article{Quinton2007CysticFL,
  title={Cystic fibrosis: lessons from the sweat gland.},
  author={Paul Marquis Quinton},
  journal={Physiology},
  year={2007},
  volume={22},
  pages={
          212-25
        }
}
Lessons from the sweat gland on cystic fibrosis (CF) began long before modern medicine became a science. In European folklore, the curse that "a child that taste salty when kissed will soon die" (Alonso y de los Ruyzes de Fonteca J. Diez Previlegios para Mugeres Prenadas. Henares, Spain, 1606) has been taken by many as a direct reference to cystic fibrosis [Busch R. Acta Univ Carol Med (Praha) 36: 13-15, 1990]. The high salt concentration in sweat from patients with CF is now accepted as almost… 
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Although patients diagnosed with atypical CF have longer life expectancies than individuals with classic CF, the long-term expected outcome for many individuals with attypical CF is unknown and it is important to counsel patients about the possibility of future illness.
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  • 2012
TLDR
The clinical features of patients with CF are predominated by respiratory, digestive and reproductive disorders, as well as the tendency to dehydration in the condition of increased sweating, which requires multidisciplinary therapeutic approach.
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The purpose of this review is to summarize the current knowledge of CF pathophysiology, including significant historic discoveries and most recent breakthroughs, and to improve understanding and awareness of this fatal disease.
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TLDR
The sweat test remains important as a diagnostic test for cystic fibrosis (CF) and there remain issues with adherence to sweat test guidelines in many countries and there are gaps in knowledge, including reference intervals for some age groups and stability of sweat samples in transport.
Cystic Fibrosis Diagnosis in Newborns, Children, and Adults.
TLDR
In older patients with a late diagnosis, the spectrum of clinical presentation can be very variable with vigilant clinicians from multiple specialties suspecting the diagnosis in conditions such as recurrent pulmonary infections, male infertility, pancreatitis, nasal polyposis, and malabsorption.
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TLDR
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Sweat gland bioelectrics differ in cystic fibrosis: a new concept for potential diagnosis and assessment of CFTR function in cystic fibrosis
TLDR
The concept that skin surface voltages arising from stimulated sweat glands can be exploited to assess expressed CFTR function in vivo and may prove to be a useful diagnostic tool is supported.
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