Cystic fibrosis: a disease in electrolyte transport

@article{Quinton1990CysticFA,
  title={Cystic fibrosis: a disease in electrolyte transport},
  author={Paul Marquis Quinton},
  journal={The FASEB Journal},
  year={1990},
  volume={4},
  pages={2709 - 2717}
}
Cystic fibrosis (CF) is a fatal genetic disease caused by abnormalities in fluid and electrolyte transport in exocrine epithelia. Both absorptive and secretory processes are affected by an underlying membrane defect in Cl− permeability. However, the impact of the defect on transport function is tissue specific. Net electrolyte absorption is decreased in the sweat duct, increased in airway epithelia, and not affected in intestine. The defect is expressed in secretion as a consistent failure in… Expand
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