Cystic Fibrosis Transmembrane Conductance Regulators (CFTR) in Biliary Epithelium of Patients with Hepatolithiasis

Abstract

Cystic fibrosis transmembrane conductance regulator (CFTR) has been considered to be involved in the regulatory pathway of biliary mucin secretion. We investigated expression of CFTR protein and mRNA in 24 livers with hepatolithiasis, in 6 with cholangiocarcinoma, and in 12 histologically normal livers. According to the histologic features of chronic proliferative cholangitis, hepatolithiasis was subdivided into inflammatory cell infiltration predominant (N = 14) and fibrosis predominant (N = 10). The mean signal density of CFTR in overall hepatolithiasis and in histologically normal livers was 1.23 ± 0.15 and 1.01 ± 0.13, respectively (P > 0.05). The CFTR protein (1.60 ± 0.18) and mRNA (1.09 ± 0.15) in inflammatory cell infiltration predominant patients were significantly higher (CFTR protein, 1.01 ± 0.13; mRNA, 0.75 ± 0.11) than in control subjects (P < 0.05), whereas those in fibrosis-predominant patients (CFTR protein, 0.72 ± 0.15; mRNA, 0.55 ± 0.13) were less than in control subjects (P < 0.05). CFTR protein (1.27 ± 0.17) in patients with cholangiocarcinoma was not different from that of control subjects (1.01 ± 0.13). CFTR expression in hepatolithiasis patients was rather heterogeneous but was closely related to the histology of bile ducts.

DOI: 10.1023/A:1016488327019

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@article{Kim2002CysticFT, title={Cystic Fibrosis Transmembrane Conductance Regulators (CFTR) in Biliary Epithelium of Patients with Hepatolithiasis}, author={Hong Ja Kim and Sung-Koo Lee and Myung-Hwan Kim and Jeoung-Min Son and Sang-Soo Lee and Ju-Sang Park and Dong-Wan Seo and Young-il Min}, journal={Digestive Diseases and Sciences}, year={2002}, volume={47}, pages={1758-1765} }