Cysteinyl leukotriene 2 receptor and protease-activated receptor 1 activate strongly correlated early genes in human endothelial cells.

@article{Uzonyi2006CysteinylL2,
  title={Cysteinyl leukotriene 2 receptor and protease-activated receptor 1 activate strongly correlated early genes in human endothelial cells.},
  author={Barbara Uzonyi and Katharina L{\"o}tzer and Steffen Jahn and Cornelia Kramer and Markus Hildner and Ellen Bretschneider and D{\"o}rte Radke and Michael R. Beer and R. Vollandt and J. Fenton Evans and Colin D. Funk and Andreas J. R. Habenicht},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 16},
  pages={6326-31}
}
Cysteinyl leukotrienes (cysLT), i.e., LTC4, LTD4, and LTE4, are lipid mediators derived from the 5-lipoxygenase pathway, and the cysLT receptors cysLT1-R/cysLT2-R mediate inflammatory tissue reactions. Although endothelial cells (ECs) predominantly express cysLT2-Rs, their role in vascular biology remains to be fully understood. To delineate cysLT2-R actions, we stimulated human umbilical vein EC with LTD4 and determined early induced genes. We also compared LTD4 effects with those induced by… CONTINUE READING

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