Cysteinyl-flavan-3-ol conjugates from grape procyanidins. Antioxidant and antiproliferative properties.

  title={Cysteinyl-flavan-3-ol conjugates from grape procyanidins. Antioxidant and antiproliferative properties.},
  author={Josep Llu{\'i}s Torres and Carles Barriocanal Lozano and Llu{\'i}s Juli{\'a} and Francisco S{\'a}nchez-Baeza and Josep M. Anglada and Josep J. Centelles and Marta Cascante},
  journal={Bioorganic & medicinal chemistry},
  volume={10 8},
New bio-based antioxidant compounds have been obtained by depolymerisation of grape polymeric flavanols in the presence of cysteine. Their preparation and purification, as well as their antiradical/antioxidant and antiproliferative properties are reported. 4beta-(S-cysteinyl)epicatechin 5, 4beta-(S-cysteinyl)catechin 6 and 4beta-(S-cysteinyl)epicatechin 3-O-gallate 7 were efficiently purified from the crude depolymerised mixture by cation-exchange chromatography and preparative reversed-phase… CONTINUE READING
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