Cysteines in the transmembrane region of major histocompatibility complex antigens are fatty acylated via thioester bonds.

@article{Kaufman1984CysteinesIT,
  title={Cysteines in the transmembrane region of major histocompatibility complex antigens are fatty acylated via thioester bonds.},
  author={James F. Kaufman and Michael S Krangel and Jack Leonard Strominger},
  journal={The Journal of biological chemistry},
  year={1984},
  volume={259 11},
  pages={7230-8}
}
Exogenous radioactive palmitic acid is incorporated post-translationally into the HLA-B and -DR heavy chains, but not HLA-A heavy chains or -DR light chains of the human B lymphoblastoid cells JY and T51 . Protease digestions localize the label to the transmembrane region of the B7 heavy chain. Both B7 and DR heavy chains have a cysteine in the transmembrane hydrophobic region, while the A2 heavy chain and DR light chains have none. Palmitic acid is covalently linked to these transmembrane… CONTINUE READING

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