Cysteine-to-alanine replacements in the Escherichia coli SoxR protein and the role of the [2Fe-2S] centers in transcriptional activation.

@article{BRADLEY1997CysteinetoalanineRI,
  title={Cysteine-to-alanine replacements in the Escherichia coli SoxR protein and the role of the [2Fe-2S] centers in transcriptional activation.},
  author={THOMASB. BRADLEY and Elena Hidalgo and Veronica Leautaud and Huangen Ding and Bruce Demple},
  journal={Nucleic acids research},
  year={1997},
  volume={25 8},
  pages={1469-75}
}
The Escherichia coli soxRS regulon activates oxidative stress and antibiotic resistance genes in two transcriptional stages. SoxR protein becomes activated in cells exposed to excess superoxide or nitric oxide and then stimulates transcription of the soxS gene, whose product in turn activates>/=10 regulon promoters. Purified SoxR protein is a homodimer… CONTINUE READING