Cysteine string protein-alpha prevents activity-dependent degeneration in GABAergic synapses.

@article{GarcaJuncoClemente2010CysteineSP,
  title={Cysteine string protein-alpha prevents activity-dependent degeneration in GABAergic synapses.},
  author={Pablo Garc{\'i}a-Junco-Clemente and Gloria Cantero and Leonardo G{\'o}mez-S{\'a}nchez and Pedro Linares-Clemente and Jos{\'e} Antonio Mart{\'i}nez-L{\'o}pez and Rafael Luj{\'a}n and Rafael Fern{\'a}ndez-Chac{\'o}n},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2010},
  volume={30 21},
  pages={7377-91}
}
The continuous release of neurotransmitter could be seen to place a persistent burden on presynaptic proteins, one that could compromise nerve terminal function. This supposition and the molecular mechanisms that might protect highly active synapses merit investigation. In hippocampal cultures from knock-out mice lacking the presynaptic cochaperone cysteine string protein-alpha (CSP-alpha), we observe progressive degeneration of highly active synaptotagmin 2 (Syt2)-expressing GABAergic synapses… CONTINUE READING