Cysteine scanning analysis of the IFM cluster in the inactivation gate of a human heart sodium channel.


UNLABELLED The conserved isoleucine-phenylalanine-methionine (IFM) hydrophobic cluster located in the III-IV linker of voltage-gated sodium channels has been identified as a major component of the fast inactivation gate in these channels. OBJECTIVES The aim of our study was to probe the contribution of each amino acids of the IFM cluster to the… (More)


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