Cysteine-rich variant surface proteins of Giardia lamblia.

  title={Cysteine-rich variant surface proteins of Giardia lamblia.},
  author={Archana Aggarwal and Jason Merritt and Theodore Elliott Nash},
  journal={Molecular and biochemical parasitology},
  volume={32 1},
Surface antigenic variation was previously demonstrated in vitro and in vivo using Giardia lamblia isolate WB. To determine whether other isolates undergo similar changes, isolates GS and N were cloned and exposed to cytotoxic anti-isolate sera or monoclonal antibodies (MAbs) specific to particular surface antigen. The surviving Giardia (progeny) and clones showed different surface antigens as judged by resistance to cytotoxicity, loss of antigens determined by surface radiolabeling, and… CONTINUE READING


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