Cysteine-rich protein 2 alters p130Cas localization and inhibits vascular smooth muscle cell migration.

@article{Chen2013CysteinerichP2,
  title={Cysteine-rich protein 2 alters p130Cas localization and inhibits vascular smooth muscle cell migration.},
  author={Chung-Huang Chen and Yen-Chun Ho and Hua-Hui Ho and Il-Chi Chang and Kathrin Kirsch and Yung-Jen Chuang and Matthew D Layne and S F Yet},
  journal={Cardiovascular research},
  year={2013},
  volume={100 3},
  pages={461-71}
}
AIMS Cysteine-rich protein (CRP) 2, a member of the LIM-only CRP family that contains two LIM domains, is expressed in vascular smooth muscle cells (VSMCs) of blood vessels and functions to repress VSMC migration and vascular remodelling. The goal of this study was to define the molecular mechanisms by which CRP2 regulates VSMC migration. METHODS AND RESULTS Transfection of VSMCs with CRP2-EGFP constructs revealed that CRP2 associated with the actin cytoskeleton. In response to… CONTINUE READING
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