Cysteine-rich domain of human ADAM 12 (meltrin alpha) supports tumor cell adhesion.

  title={Cysteine-rich domain of human ADAM 12 (meltrin alpha) supports tumor cell adhesion.},
  author={Kousuke Iba and Reidar Albrechtsen and Brent J. Gilpin and Frosty Loechel and Ulla M. Wewer},
  journal={The American journal of pathology},
  volume={154 5},
The ADAMs (A disintegrin and metalloprotease) comprise a family of membrane-anchored cell surface proteins with a putative role in cell-cell and/or cell-matrix interactions. By immunostaining, ADAM 12 (meltrin alpha) was up-regulated in several human carcinomas and could be detected along the tumor cell membranes. Because of this intriguing staining pattern, we investigated whether human ADAM 12 supports tumor cell adhesion. Using an in vitro assay using recombinant polypeptides expressed in… CONTINUE READING
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