Cysteine residues in the C-terminal lobe of Src: their role in the suppression of the Src kinase


To evaluate the function of cysteine residues of the Src kinase, we constructed a series of Src mutants in which some of cyteines were replaced to alanines. With these mutants, we studied the effect of SH-alkylating agents, N-[p-(2-benzimidazolyl)phenyl] maleimide (BIPM) and N-(9-acridinyl) maleimide (NAM), on their kinase activity. Of 10 cysteine residues… (More)
DOI: 10.1038/sj.onc.1206286


4 Figures and Tables