Cysteine residues as catalysts for covalent peptide and protein modification: a role for thiyl radicals?

@article{Schneich2011CysteineRA,
  title={Cysteine residues as catalysts for covalent peptide and protein modification: a role for thiyl radicals?},
  author={Christian Sch{\"o}neich},
  journal={Biochemical Society transactions},
  year={2011},
  volume={39 5},
  pages={
          1254-9
        }
}
Cysteine thiyl radicals engage in reversible intramolecular hydrogen-transfer reactions with amino acid residues in peptides and proteins. These reactions can be experimentally demonstrated through covalent hydrogen-deuterium exchange when experiments are carried out in (2)H2O. To this end, hydrogen-transfer reactions have been observed between cysteine thiyl radicals and glycine, alanine, serine, valine and leucine in both model peptides and a protein, insulin. The relevance of such reactions… CONTINUE READING

Figures and Topics from this paper.

References

Publications referenced by this paper.
SHOWING 1-10 OF 35 REFERENCES