Cysteine proteinases in rat dorsal root ganglion and spinal cord, with special reference to the co-localization of these enzymes with calcitonin gene-related peptide in lysosomes.

Abstract

To examine the localization of lysosomal cysteine proteinases, cathepsins B, H, and L, and their correlation with a neuropeptide, calcitonin gene-related peptide (CGRP) in nerve cells, immunocytochemistry was applied to rat dorsal root ganglion (DRG) and spinal cord (SC) of lumbar segments. By light microscopy, granular immunodeposits for cathepsins B and L… (More)

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