Cysteine proteinases and metastasis

  title={Cysteine proteinases and metastasis},
  author={Bonnie F Sloane and Kenneth V. Honn},
  journal={Cancer and Metastasis Reviews},
Cysteine proteinases are a subclass of endopeptidases which require activation by thiol reagents. A tumor cysteine proteinase which appears to be related to lysosomal cathepsin B has been implicated in the ability of tumor cells to invade the extracellular matrix and to metastasize to secondary sites. Lysosomal cathepsin B can degrade such components of the extracellular matrix as collagen, fibronectin and proteoglycans. Activity of this cathepsin B-like cysteine proteinase (CB) has been… CONTINUE READING
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