Cysteine proteinases and metastasis

@article{Sloane1984CysteinePA,
  title={Cysteine proteinases and metastasis},
  author={Bonnie F Sloane and Kenneth V. Honn},
  journal={Cancer and Metastasis Reviews},
  year={1984},
  volume={3},
  pages={249-263}
}
Cysteine proteinases are a subclass of endopeptidases which require activation by thiol reagents. A tumor cysteine proteinase which appears to be related to lysosomal cathepsin B has been implicated in the ability of tumor cells to invade the extracellular matrix and to metastasize to secondary sites. Lysosomal cathepsin B can degrade such components of the extracellular matrix as collagen, fibronectin and proteoglycans. Activity of this cathepsin B-like cysteine proteinase (CB) has been… CONTINUE READING
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Association of cysteine proteinase activities with viable tumor cells isolated from rodent primary subcutaneous tumors ( Abstract )

  • J Crissman, B Sloane, R Ryan
  • Proc Am Assoc Cancer Res
  • 1984

Correlation of cathepsin B and metastatic potential in malignant neoplasia ( Abstract )

  • BF Sloane, PG Cavanaugh, KV Honn
  • Lab Invest
  • 1984

Production of monoclonal antibodies against eathepsin B - like enzyme derived from urine of gynecologic cancer patients ( Abstract )

  • JP Perras, Sevin B-U
  • Proc Am Assoc Cancer Res
  • 1984

Purification and properties of a cathepsin B - like enzyme from human tumors : comparison with cathepsin B isolated from human liver and spleen ( Abstract )

  • BF Sloane, Dunn, KV Honn
  • Proc Am Assoc Cancer Res
  • 1984

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