Cysteine proteases: Battling pathogenic parasitic protozoans with omnipresent enzymes.

  title={Cysteine proteases: Battling pathogenic parasitic protozoans with omnipresent enzymes.},
  author={Aadish Rawat and Mrinalini Roy and Anupam Jyoti and Sanket Kaushik and Kuldeep Verma and Vijay Kumar Srivastava},
  journal={Microbiological research},
Probing the Peculiarity of EhRabX10, a pseudoRab GTPase, from the Enteric Parasite Entamoeba histolytica through In Silico Modeling and Docking Studies
This in silico study provides an introduction to the characterization of the atypical EhRabX10 and set the stage for future explorations into the mechanisms of nucleotide recognition, binding, and hydrolysis employed by the pseudoEhRab GTPase family.
A Review: Natural and Synthetic Compounds Targeting Entamoeba histolytica and Its Biological Membrane
A review aims to observe the updated trend of the research regarding the biological membranes of E. histolytica from 2015 to 2021, which may help furtherResearch regarding the drug targeting the biological membrane.
The flip side of reactive oxygen species in the tropical disease‐Amoebiasis
Insight is given into a solution that could be a potent source in generating new treatment and vaccines for amoebiasis by targeting parasite development and why NOX inhibitors, a potent antiparasitic drug, is not effective for in vivo purposes.
A Case of Leishmaniasis Infantum Kala-Azar in an Immunocompetent 49-Year-Old Man
An immunocompetent 45-year-old Cuban-American man presented with worsening knee pain and swelling despite antibiotic therapy and received two courses of amphotericin B lipid complex with a 28-day course of miltefosine, which resulted in clinical improvement.


Cysteine proteases in protozoan parasites
Cysteine proteases (CPs) play key roles in the pathogenesis of protozoan parasites, including cell/tissue penetration, hydrolysis of host or parasite proteins, autophagy, and evasion or modulation of
Structural Insights Into Key Plasmodium Proteases as Therapeutic Drug Targets
It is concluded that Plasmodium proteases are suitable as multistage targets for designing novel drugs with new modes of action to combat malaria.
Averting transmission: A pivotal target to manage amoebiasis.
A perspective on essential metabolic processes and the associated molecules that can be targeted efficaciously to prevent the transmission of amoebiasis are presented, thus managing the disease, and proving to be a fruitful endeavour.
Cysteine protease inhibitors as chemotherapy: lessons from a parasite target.
It is reported that specific cysteine protease inhibitors kill Leishmania parasites in vitro, at concentrations that do not overtly affect mammalian host cells.
Proteases from Entamoeba spp. and Pathogenic Free-Living Amoebae as Virulence Factors
Proteases that affect mucin, extracellular matrix, immune system components, and diverse tissues and cells are included, based on studies in amoebic cultures and animal models.
Leishmania Cysteine Proteinases: From Gene to Subunit Vaccine
An overview of the current knowledge on genetic vaccination used against leishmaniasis and the importance of CP genes for such an approach is given.
The ways of a killer: how does Entamoeba histolytica elicit host cell death?
Progress has been made in determining that cytotoxicity requires parasite Gal (galactose)/GalNAc (N-acetylgalactosamine) lectin-mediated adherence, target cell calcium influx, dephosphorylation and activation of caspase 3.
Proteinases as virulence factors in Leishmania spp. infection in mammals
A review of studies that have explored the role of proteinases as virulence factors that promote parasite survival and immune modulation in the mammalian host reinforces the importance of the parasite proteinases, which are interesting candidates for new chemo or immunotherapies, in the clinical manifestations of leishmaniasis.