Cysteine protease activity is required for surfactant protein B processing and lamellar body genesis.

Abstract

Surfactant protein (SP)-B is essential for lamellar body genesis and for the final steps in proSP-C post-translational processing. The mature SP-B protein is derived from multistep processing of the primary translation product proSP-B; however, the enzymes required for these events are currently unknown. Recent ultrastructural colocalization studies have… (More)

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Cite this paper

@article{Guttentag2003CysteinePA, title={Cysteine protease activity is required for surfactant protein B processing and lamellar body genesis.}, author={Susan H Guttentag and Lauren C Robinson and Peggy X. Zhang and Frank E. Brasch and Frank Buehling and Michael Beers}, journal={American journal of respiratory cell and molecular biology}, year={2003}, volume={28 1}, pages={69-79} }