Cysteine peptidases of mammals: their biological roles and potential effects in the oral cavity and other tissues in health and disease.

@article{Dickinson2002CysteinePO,
  title={Cysteine peptidases of mammals: their biological roles and potential effects in the oral cavity and other tissues in health and disease.},
  author={Douglas P Dickinson},
  journal={Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists},
  year={2002},
  volume={13 3},
  pages={238-75}
}
Cysteine peptidases (CPs) are phylogenetically ubiquitous enzymes that can be classified into clans of evolutionarily independent proteins based on the structural organization of the active site. In mammals, two of the major clans represented in the genome are: the CA clan, whose members share a structure and evolutionary history with papain; and the CD clan, which includes the legumains and caspases. This review focuses on the properties of these enzymes, with an emphasis on their potential… CONTINUE READING

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