Cysteine pK(a) values for the bacterial peroxiredoxin AhpC.

@article{Nelson2008CysteinePV,
  title={Cysteine pK(a) values for the bacterial peroxiredoxin AhpC.},
  author={Kimberly J. Nelson and D. Parsonage and Andrea Hall and P. Karplus and L. Poole},
  journal={Biochemistry},
  year={2008},
  volume={47 48},
  pages={
          12860-8
        }
}
Salmonella typhimurium AhpC is a founding member of the peroxiredoxin family, a ubiquitous group of cysteine-based peroxidases with high reactivity toward hydrogen peroxide, organic hydroperoxides, and peroxynitrite. For all of the peroxiredoxins, the catalytic cysteine, referred to as the peroxidatic cysteine (C(P)), acts as a nucleophile in attacking the peroxide substrate, forming a cysteine sulfenic acid at the active site. Because thiolates are far stronger nucleophiles than thiol groups… Expand
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