Cysteine p K a Values for the Bacterial

  title={Cysteine p K a Values for the Bacterial},
  author={Peroxiredoxin AhpC and Kimberly J. Nelson and Derek Parsonage and Andrea A Hall and P. Andrew Karplus and Leslie B. Poole},
Salmonella typhimurium AhpC is a founding member of the peroxiredoxin family, a ubiquitous group of cysteine-based peroxidases with high reactivity toward hydrogen peroxide, organic hydroperoxides, and peroxynitrite. For all of the peroxiredoxins, the catalytic cysteine, referred to as the peroxidatic cysteine (CP), acts as a nucleophile in attacking the peroxide substrate, forming a cysteine sulfenic acid at the active site. Because thiolates are far stronger nucleophiles than thiol groups, it… CONTINUE READING