Cysteine mutant of mammalian GPx4 rescues cell death induced by disruption of the wild-type selenoenzyme.

@article{Mannes2011CysteineMO,
  title={Cysteine mutant of mammalian GPx4 rescues cell death induced by disruption of the wild-type selenoenzyme.},
  author={Alexander M Mannes and Alexander Seiler and Valentina Bosello and Matilde Maiorino and Marcus Conrad},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2011},
  volume={25 7},
  pages={
          2135-44
        }
}
Selenoproteins are expressed in many organisms, including bacteria, insects, fish, and mammals. Yet, it has remained obscure why some organisms rely on selenoproteins while others, like yeast and plants, express Cys-containing homologues. This study addressed the possible advantage of selenocysteine (Sec) vs. Cys in the essential selenoprotein glutathione peroxidase 4 (GPx4), using 4-hydroxy-tamoxifen-inducible Cre-excision of loxP-flanked GPx4 alleles in murine cells. Previously, it was shown… CONTINUE READING

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