Cysteine cathepsins are not critical for TNF-alpha-induced cell death in T98G and U937 cells.

@article{Klari2009CysteineCA,
  title={Cysteine cathepsins are not critical for TNF-alpha-induced cell death in T98G and U937 cells.},
  author={Martina Klari{\'c} and Sun Tao and Veronika Stoka and Boris Turk and Vito Turk},
  journal={Biochimica et biophysica acta},
  year={2009},
  volume={1794 9},
  pages={1372-7}
}
The tumor necrosis factor (TNF) is a cytokine known to be an important mediator of apoptosis and inflammation. It has been implicated in the pathogenesis of a number of diseases, including cancer and rheumatoid arthritis. TNF apoptosis has been known for a number of years to be critically dependent on caspases; however, recently it has been suggested that cysteine cathepsins might also be involved in the pathway. In the present work the hypothesis that cathepsins can act as an essential… CONTINUE READING