Cysteine cathepsins (proteases)--on the main stage of cancer?

  title={Cysteine cathepsins (proteases)--on the main stage of cancer?},
  author={Vito Turk and Janko Kos and Boris Turk},
  journal={Cancer cell},
  volume={5 5},
Cysteine cathepsins are involved in degradation of extracellular matrix, facilitating growth, invasion, and metastasis of tumor cells, in tumor angiogenesis, in apoptosis, and in events of inflammatory and immune responses. In this issue of Cancer Cell, demonstrate association of increased cathepsins activity with angiogenic vasculature and invasive fronts of carcinomas during tumorigenesis in transgenic mouse models using activity-based chemical probes and in vivo imaging. Moreover, this study… CONTINUE READING