Cysteine cathepsins: multifunctional enzymes in cancer

@article{Mohamed2006CysteineCM,
  title={Cysteine cathepsins: multifunctional enzymes in cancer},
  author={Mona Mohamed and Bonnie F Sloane},
  journal={Nature Reviews Cancer},
  year={2006},
  volume={6},
  pages={764-775}
}
Cysteine cathepsins are highly upregulated in a wide variety of cancers by mechanisms ranging from gene amplification to post-transcriptional modification. Their localization within intracellular lysosomes often changes during neoplastic progression, resulting in secretion of both inactive and active forms and association with binding partners on the tumour cell surface. Secreted, cell-surface and intracellular cysteine cathepsins function in proteolytic pathways that increase neoplastic… CONTINUE READING
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