Cysteine-based cross-linking approach to study inter-domain interactions in ion channels.

Abstract

Cysteine contains a highly reactive thiol group and therefore under oxidizing conditions a disulfide bond can form between a pair of cysteines that are juxtaposed in the close vicinity, which can be only reversed by reducing agents. These attributes have been elegantly exploited to study the functional role of an interaction or contact between two adjacent… (More)
DOI: 10.1007/978-1-62703-351-0_21

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