Cysteine and glycine supplementation modulate the metabolic response to tumor necrosis factor alpha in rats fed a low protein diet.

@article{Grimble1992CysteineAG,
  title={Cysteine and glycine supplementation modulate the metabolic response to tumor necrosis factor alpha in rats fed a low protein diet.},
  author={Robert Francis Grimble and Alan A Jackson and Chandarika Persaud and M J Wride and Francisco Delers and Reto Engler},
  journal={The Journal of nutrition},
  year={1992},
  volume={122 11},
  pages={2066-73}
}
Responses to cytokines entail synthesis of substances rich in cysteine and glycine, such as glutathione (GSH), metallothionein and some plasma proteins. To examine the importance of an adequate supply of cysteine and glycine, we fed rats a low protein diet supplemented with L-cysteine and glycine, separately or in combination, or L-alanine, or a high protein diet for 1 wk before injection with tumor necrosis factor alpha (TNF) or saline. The high protein diet-fed group had greater liver weight… CONTINUE READING

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