Cysteine Sulfenylation Directs IRE-1 to Activate the SKN-1/Nrf2 Antioxidant Response.

@article{Hourihan2016CysteineSD,
  title={Cysteine Sulfenylation Directs IRE-1 to Activate the SKN-1/Nrf2 Antioxidant Response.},
  author={John M Hourihan and Lorenza E Moronetti Mazzeo and L Paulette Fern{\'a}ndez-C{\'a}rdenas and T. Keith Blackwell},
  journal={Molecular cell},
  year={2016},
  volume={63 4},
  pages={553-566}
}
Emerging evidence suggests that many proteins may be regulated through cysteine modification, but the extent and functions of this signaling remain largely unclear. The endoplasmic reticulum (ER) transmembrane protein IRE-1 maintains ER homeostasis by initiating the unfolded protein response (UPR(ER)). Here we show in C. elegans and human cells that IRE-1 has a distinct redox-regulated function in cytoplasmic homeostasis. Reactive oxygen species (ROS) that are generated at the ER or by… CONTINUE READING
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