Cysteine-Rich Domain Isoforms of the Neuregulin-1 Gene Are Required for Maintenance of Peripheral Synapses

  title={Cysteine-Rich Domain Isoforms of the Neuregulin-1 Gene Are Required for Maintenance of Peripheral Synapses},
  author={Deon Wolpowitz and T. B. Mason and Paula Dietrich and M. Mendelsohn and D. Talmage and L. Role},
  • Deon Wolpowitz, T. B. Mason, +3 authors L. Role
  • Published 2000
  • Biology, Medicine
  • Neuron
  • Neuregulin-1 (NRG-1) signaling has been implicated in inductive interactions between pre- and postsynaptic partners during synaptogenesis. We used gene targeting to selectively disrupt cysteine-rich domain-(CRD-) containing NRG-1 isoforms. In CRD-NRG-1-/-mice, peripheral projections defasciculated and displayed aberrant branching patterns within their targets. Motor nerve terminals were transiently associated with broad bands of postsynaptic ACh receptor (AChR) clusters. Initially, Schwann cell… CONTINUE READING
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