Cysteine 144 is a key residue in the copper reduction by the beta-amyloid precursor protein.

  title={Cysteine 144 is a key residue in the copper reduction by the beta-amyloid precursor protein.},
  author={Francisca H. Ruiz and Marta Gonz{\'a}lez and M E Bodini and Carlos Opazo and Nibaldo C Inestrosa},
  journal={Journal of neurochemistry},
  volume={73 3},
The beta-amyloid precursor protein (beta-APP) contains a copper-binding site localized between amino acids 135 and 156 (beta-APP(135-156)). We have employed synthetic beta-APP peptides to characterize their capacities to reduce Cu(II) to Cu(I). Analogues of the wild-type beta-APP(135-156) peptide, containing specific amino acid substitutions, were used to establish which residues are specifically involved in the reduction of copper by beta-APP(135-156). We report here that beta-APP's copper… CONTINUE READING

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