Cysteamine Gliopathy in situ: A Cellular Stress Model for the Biogenesis of Astrocytic Inclusions

@article{Schipper1993CysteamineGI,
  title={Cysteamine Gliopathy in situ: A Cellular Stress Model for the Biogenesis of Astrocytic Inclusions},
  author={Hyman M. Schipper and Marc B. Mydlarski and X Wang},
  journal={Journal of Neuropathology and Experimental Neurology},
  year={1993},
  volume={52},
  pages={399–410}
}
In cultured astroglia, cysteamine induces the accumulation of peroxidase-positive cytoplasmic inclusions in the context of a generalized cellular stress response. In the present study, systemic cysteamine administration over a 3 week period induced HSP27, 72, 90, and GRP94 (stress proteins) in astrocytes and significantly increased numbers of peroxidase-positive astrocytic inclusions in the various brain regions relative to controls. Similar patterns of HSP expression were also observed at 24… 
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Astrocytes in subcortical regions of the mammalian brain progressively accumulate iron-rich, autofluorecent cytoplasmic inclusions as a function of aging. Cysteamine (CSH) accelerates the appearance
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